免费播看完整大片

科学研究
20210622 The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response
发布时间:2021-06-30  来源:  阅读次数:

Li, C., Feng, L., Luo, W.W., Lei, C.Q., Li, M., and Shu, H.B.* (2021). The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response. Cell Discov 7, 46.(舒红兵)

 

Abstract

MITA (also known as STING) is an ER-located adaptor protein, which mediates DNA-triggered innate immune response and is critically involved in autoimmune diseases and tumorigenesis. MITA is regulated by post-translational modifications, but how post-transcriptional mechanisms are involved in the regulation of MITA is still largely unknown. Here, we identified the RNA-binding protein LUC7L2 as a negative regulator of DNA virus-triggered innate immune response. LUC7L2-deficient mice exhibited resistance to lethal herpes simplex virus 1 (HSV-1) infection and reduced HSV-1 loads in the brain. Mechanistically, LUC7L2 directly bound to intron 3 of MITA precursor messenger RNA, inhibited its splicing and promoted its nonsense-mediated decay, leading to its downregulation at protein level. LUC7L2-deficient cells had markedly increased MITA level, leading to heightened innate antiviral response. Finally, LUC7L2 was induced following HSV-1 infection. Our findings reveal a feedback negative post-transcriptional regulatory mechanism for regulation of MITA-mediated innate immune response to viral and aberrant cellular DNA.


全文链接请见:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217528/


 

 

地 址:湖北省武汉市武昌区东湖路115号 邮政编码:430071 电 话:027-68750205  邮 箱:mri@whu.edu.cn

CopyRight ? 2016  版权所有:武汉大学免费播看完整大片

免费播看完整大片-免费费看很色大片-免费大片黄在线观看高清观看